A composite cytology-histology endpoint allows a more accurate estimate of anal high-grade squamous intraepithelial lesion prevalence

DA Machalek; IM Poynten; F Jin; RJ Hillman; DJ Templeton; C Law; JM Roberts; SN Tabrizi; SM Garland; A Farnsworth; CK Fairley; AE Grulich; B Acraman; M Adams; A Carr; S Carroll; D Cooper; A Cornall; L Crampton; D Ekman; K Fairley; L Feeney; E Fraissard; K Howard; M Law; K McCaffery; R McDonald; P McGrath; R Mellor; R Norris; M O'Dwyer; S Pendlebury; K Petoumenos; S Phillips; G Prestage; A Richards; L Schema; D Seeds; E Segelov; J Thurloe; W Tong; R Varma

Journal article

A composite cytology-histology endpoint allows a more accurate estimate of anal high-grade squamous intraepithelial lesion prevalence

DA Machalek, IM Poynten, F Jin, RJ Hillman, DJ Templeton, C Law, JM Roberts, SN Tabrizi, SM Garland, A Farnsworth, CK Fairley, AE Grulich, B Acraman, M Adams, A Carr, S Carroll, D Cooper, A Cornall, L Crampton, D Ekman Show all

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2016

DOI: 10.1158/1055-9965.EPI-15-1106

Abstract

Background: There is debate about the accuracy of anal cytology and high-resolution anoscopy (HRA), in the diagnosis of anal human papillomavirus (HPV)-related squamous intraepithelial lesions (SIL). Few studies have performed both simultaneously in a large sample of high-risk individuals. Methods: At baseline in a community-based cohort of HIVinfected and uninfected homosexual men ages ≥35 years in Sydney, Australia, all men underwent anal swabbing for cytology and HPV genotyping, and HRA-guided biopsy. We evaluated the separate and combined diagnostic accuracy of cytology and histology, based on a comparison with the prevalence of HPV16 and other high-risk (HR) HPV. We examined trends in H..

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University of Melbourne Researchers

Suzanne Wark Author

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Grants

Awarded by National Health and Medical Research Council Program Grant

Awarded by Cancer Council New South Wales Strategic Research Partnership Program Grant

Funding Acknowledgements

The SPANC study was funded by a National Health and Medical Research Council Program Grant (Sexually transmitted infections: Causes, consequences and interventions Grant #568971; to A.E. Grulich and C.K. Fairley) and a Cancer Council New South Wales Strategic Research Partnership Program Grant (preventing morbidity and mortality from anal cancer grant #13 11; to A.E. Grulich, I.M. Poynten, F. Jin, R.J. Hillman, D.J. Templeton, S.N. Tabrizi, S.M. Garland, A. Farnsworth, and C.K. Fairley). Cytologic testing materials were provided by Hologic Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales, and funded by the Australian Government of Health and Ageing.